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What we deliver here is a blueprint of a brain circuit and nicotine receptor subtype that is critically important for nicotines aversive properties. The work was supported by the National Institutes of Health (1R01DA042889), Californias Tobacco-Related Disease Research Program (26IP-0035), the One Mind Foundation (047483), the Brain Research Foundation (BRFSG-2015-7) and the Wayne and Gladys Valley Foundation